HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → 3-[4-(p-Toluenesulfonyloxy)butyl]-1H-indole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 3-(4-Hydroxybutyl)-1H-indole-5-carbonitrile | HCID 12150985 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[4-(p-Toluenesulfonyloxy)butyl]-1H-indole-5-carbonitrile | HCID 56952267 | — |
Reaction Steps
3-[4-(p-Toluenesulfonyloxy)butyl]-1H-indole-5-carbonitrile was prepared by reacting 3-(4-hydroxybutyl)-1H-indole-5-carbonitrile with p-toluenesulfonyl chloride in the presence of base in dichloromethane as per the process exemplified in example 2 of Chinese Patent Application Publication No. CN 102267932 A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09399630B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-7ec02b1befcf4e9aacb6d855bae4a083 |
| Source note | uspto-grants-2016_07 |