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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1056559Generated: November 1, 2026

Acetyl chloride → HCID 73387724, compound

https://huagongshe.com/reaction/1056559

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetyl chlorideHCID 6367—
ReactantTriethylamineHCID 8471—
ReactantVemurafenibHCID 42611257—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 73387724HCID 73387724—

Reaction Steps

The title compound was prepared according to the procedure as described in Example 3 using N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (0.2 g, 0.41 mmol), triethylamine (1 mL) and acetyl chloride (116 μL, 1.64 mmol) in 1,4-dioxane (10 mL). The title compound was obtained as a white solid (69 mg, 31.8%). The title compound was characterized by LCMS and 1H NMR as shown below:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09399639B2
Source datasetuspto-grants-2016_07
ORD IDord-b8a1c65a108b428b9812e90ee71973d3
Source noteuspto-grants-2016_07