Potassium Hydroxide → HCID 73388149, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure as described in Example 14 Step 2 using N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (0.1 g, 0.2 mmol) in DMF (0.9 mL), KOH (23 mg, 0.4 mmol) and a solution of tert-butyl 4-(2-(chloromethoxy)-2-oxoethyl)piperidine-1-carboxylate (60 mg, 0.2 mmol) in DMF (100 μL). The crude product was purified by a silica gel column chromatography (PE/EtOAc (v/v)=3/1 to 2/1) to afford the title compound as a white solid (86 mg, 56.6%). The title compound was characterized by LC-MS and 1H NMR as shown below:

Provenance & Evidence