HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 73388153, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86711094 | HCID 86711094 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 73388153 | HCID 73388153 | 111.6% |
Reaction Steps
A mixture of (5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate (0.33 g, 0.48 mmol) and a saturated solution of HCl in EtOAc (3 mL) was stirred at rt for 3 h. The mixture was filtered to afford the title compound as a white solid (168 mg, 56%). The title compound was characterized by LCMS and 1H NMR as shown below:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09399639B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-f2f26bec961743129a158c061b76bb7a |
| Source note | uspto-grants-2016_07 |