HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 73388155, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86711095 | HCID 86711095 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 73388155 | HCID 73388155 | 145.5% |
Reaction Steps
A mixture of (5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl 2-((tert-butoxycarbonyl)amino)-2-methylpropanoate (339 mg, 0.48 mmol) and a saturated solution of HCl in EtOAc (3 mL) was stirred at rt for 5 h. The resulting mixture was filtered to afford the title compound as a white solid (224 mg, 72.6%). The title compound was characterized by LC-MS and 1H NMR as shown below:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09399639B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-4bda35134f014443b3e607bdb1338a70 |
| Source note | uspto-grants-2016_07 |