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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1056583Generated: November 1, 2026

Hydrochloric Acid → HCID 73388155, compound

https://huagongshe.com/reaction/1056583

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 86711095HCID 86711095—
SolventEthyl AcetateHCID 8857—
ProductHCID 73388155HCID 73388155145.5%

Reaction Steps

A mixture of (5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl 2-((tert-butoxycarbonyl)amino)-2-methylpropanoate (339 mg, 0.48 mmol) and a saturated solution of HCl in EtOAc (3 mL) was stirred at rt for 5 h. The resulting mixture was filtered to afford the title compound as a white solid (224 mg, 72.6%). The title compound was characterized by LC-MS and 1H NMR as shown below:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09399639B2
Source datasetuspto-grants-2016_07
ORD IDord-4bda35134f014443b3e607bdb1338a70
Source noteuspto-grants-2016_07