HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86711101, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86711100 | HCID 86711100 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86711101 | HCID 86711101 | 114.9% |
Reaction Steps
A mixture of 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate (0.29 g, 0.39 mmol) and a saturated solution of HCl in EtOAc (4 mL) was stirred at rt for 2 h. The mixture was filtered to give the title compound as a white solid (0.15 g, 57%). The title compound was characterized by LC-MS and 1H NMR as shown below:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09399639B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-c85dc1501e6f4836bbc9124b2f5f5f1a |
| Source note | uspto-grants-2016_07 |