Ethanol → Carbonic acid, 1-chloroethyl ethyl ester
Reaction equation
Cl[C:2]([O:4][CH:5]([Cl:7])[CH3:6])=[O:3].C([OH:10])C.N1[CH:16]=[CH:15]C=CC=1>C(Cl)Cl>[C:2](=[O:10])([O:3][CH2:15][CH3:16])[O:4][CH:5]([Cl:7])[CH3:6]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound was prepared according to the procedure as described in Example 26 step 1 using a solution of 1-chloroethyl chloroformate (10 g, 69.9 mmol) in DCM (200 mL), a mixture of ethanol (4.5 mL, 77.2 mmol) and pyridine (6.8 mL, 84.5 mmol) in DCM (50 mL). The title compound was obtained as colorless oil (9.32 g, 87.7%) and was used in the next step without further purification. The title compound was characterized by 1H NMR as shown below:
Workup
- customThe title compound was prepared
Sources & evidence
- ORD record
- ord-7f7df2db808742f396ca42e08615730e
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09399639B2
Reaction notes
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