HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 10566Generated: October 25, 2026
Dimethylformamide → HCID 178418825, compound
https://huagongshe.com/reaction/10566
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | HCID 178418932 | HCID 178418932 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 178418825 | HCID 178418825 | — |
Reaction Steps
A suspension of Intermediate 121 (113.7 mg), zinc cyanide (19.4 mg, Wako Pure Chemical Industries), tris(dibenzylideneacetone)dipalladium(0) (24.0 mg) and 1,1′-bis(diphenylphosphino)ferrocene (35.3 mg, Tokyo Kasei Kogyo) in DMF (2 ml) was stirred at 120° C. for 19 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (34.9 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07094789B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-77836b6fe0cb4c828f1476a14df81196 |
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| Source note | uspto-grants-2006_08 |
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