HRID1056637
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
产物
![tert-Butyl 9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate 分子结构式](/api/mol/59311817/svg/220x140.svg)
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 70 °C
PROCEDURE
实验过程
To a solution of tert-butyl 4-formylpiperidine-1-carboxylate (10.0 g, 46.9 mmol) and KOH (1.3 g, 23.5 mmol) in EtOH (200 mL) was added but-3-en-2-one (3.9 g, 56.3 mmol), the mixture was stirred at 70° C. for 16 h and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/4) to give the product as brown oil (5.2 g, 41.8%).
WORKUP
后处理
- concentrationconcentrated in vacuo
- customThe residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/4)