Diisopropylethylamine → HCID 118390170, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	2,3-Dimethyl-6-amino-2H-indazole hydrochloride	HCID 46864001	—
Reactant	Tert-butyl 3-[(2,5-dichloropyrimidin-4-yl)amino]-9-azaspiro[5.5]undecane-9-carboxylate	HCID 118390013	—
Solvent	1-Butanol	HCID 263	—
Product	HCID 118390170	HCID 118390170	19.8%

Reaction Conditions

Temperature	150 °C

Reaction Steps

To a suspension of tert-butyl 9-((2,5-dichloropyrimidin-4-yl)amino)-3-azaspiro[5.5]undecane-3-carboxylate (659.8 mg, 1.59 mmol) and 2,3-dimethylindazol-6-amine hydrochloride (580.6 mg, 2.94 mmol) in n-BuOH (6 mL) was added DIPEA (755.5 mg, 5.79 mmol). The reaction mixture was stirred at 150° C. under microwave radiation for 2 h and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=2/1) to give the title compound as a yellow solid (169.7 mg, 19.8%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09399637B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-ebc337cf1109441d8915e8ddcd11967c
Source note	uspto-grants-2016_07