Ethyl bromoacetate → HCID 8027287, compound

Participants

Reaction Steps

To a stirred solution of crude hydroxy-pyridine 21c (4.92 g, 21.1 mmol) in acetone is added potassium carbonate (4.36 g, 31.6 mmol) and ethyl bromoacetate (3.5 mL, 31.6 mmol). The mixture is refluxed for 1 h, then quenched with water and extracted with EtOAc. The combined organic layers are washed with brine, dried (Na2SO4), filtered and concentrated to provide crude ester 21d, which is used as such in the next step.

Provenance & Evidence