1-Hydroxybenzotriazole → 2,6-Dichloro-quinoline-5-carboxylic acid (4,4-difluorocyclohexylmethyl)-amide

Participants

Reaction Steps

A mixture of 2,6-dichloro-quinoline-5-carboxylic acid (1500.00 mg; 6.20 mmol; 1.00 eq.), (4,4-difluoro-cyclohexyl)-methylamine (1380.48 mg; 7.44 mmol; 1.20 eq.), (3-dimethylamino-propyl)-ethyl-carbodiimide hydrochloride (1425.53 mg; 7.44 mmol; 1.20 eq.) (EDCI), benzotriazol-1-ol (1004.81 mg; 7.44 mmol; 1.20 eq.) (HOBt) and ethyl-diisopropyl-amine (2402.70 mg; 18.59 mmol; 3.00 eq.) in DMF (10.0 mL) was stirred at room temperature overnight. The mixture was poured into water, the solid was collected by filtration and washed with ethyl acetate, then dried over. The product, 2,6-dichloro-N-((4,4-difluorocyclohexyl)methyl)quinoline-5-carboxamide (1.78 g, 77% yield) was used for the next reaction without further purification. m/z: 374 [M+H]+

Provenance & Evidence