3-Methoxy-1-propanol → HCID 118566611, compound

HRID 1056673Notes

Reaction equation

HRID 1056673 reaction equation
[F:1][C:2]1([F:24])[CH2:7][CH2:6][CH:5]([CH2:8][NH:9][C:10]([C:12]2[C:13]3[CH:14]=[CH:15][C:16](Cl)=[N:17][C:18]=3[CH:19]=[CH:20][C:21]=2[Cl:22])=[O:11])[CH2:4][CH2:3]1.[CH3:25][O:26][CH2:27][CH2:28][CH2:29][OH:30]>>[F:1][C:2]1([F:24])[CH2:7][CH2:6][CH:5]([CH2:8][NH:9][C:10]([C:12]2[C:13]3[CH:14]=[CH:15][C:16]([O:30][CH2:29][CH2:28][CH2:27][O:26][CH3:25])=[N:17][C:18]=3[CH:19]=[CH:20][C:21]=2[Cl:22])=[O:11])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 741163-Methoxy-1-propanolHCID 1185559652,6-Dichloro-quinoline-5-carboxylic acid (4,4-difluorocyclohexylmethyl)-amide

Product 1

HCID 118566611HCID 118566611, compound

Procedure

The title compound was synthesized according to the procedure described in example 9 using 2,6-dichloro-quinoline-5-carboxylic acid (4,4-difluoro cyclohexyl methyl)-amide and 3-methoxy-propan-1-ol. 1H NMR (400 MHz, DMSO-d6): δ 8.79-8.82 (m, 1H), 7.95 (d, J=9.11 Hz, 1H), 7.79 (d, J=9.01 Hz, 1H), 7.70 (d, J=9.01 Hz, 1H), 7.12 (d, J=9.12 Hz, 1H), 4.45 (t, J=13.2 Hz, 2H), 3.49 (t, J=12.61 Hz, 2H), 3.25 (s, 5H), 1.97-2.04 (m, 4H), 1.80-1.86 (m, 3H), 1.73-1.76 (m, 2H), 1.23-1.32 (m, 2H). m/z: 427.0 [M+H]+

Sources & evidence

ORD record
ord-083b208dfb2c468f910f6fe970a5c27a
Source dataset
uspto-grants-2016_07
Patent number
US09399623B2

Reaction notes

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