3-(Methylamino)pyrrolidine → HCID 118566552, compound

HRID 1056683Notes

Reaction equation

HRID 1056683 reaction equation
[F:1][C:2]1([F:24])[CH2:7][CH2:6][CH:5]([CH2:8][NH:9][C:10]([C:12]2[C:13]3[CH:14]=[CH:15][C:16](Cl)=[N:17][C:18]=3[CH:19]=[CH:20][C:21]=2[Cl:22])=[O:11])[CH2:4][CH2:3]1.[CH3:25][NH:26][CH:27]1[CH2:31][CH2:30][NH:29][CH2:28]1>>[F:1][C:2]1([F:24])[CH2:7][CH2:6][CH:5]([CH2:8][NH:9][C:10]([C:12]2[C:13]3[CH:14]=[CH:15][C:16]([N:29]4[CH2:30][CH2:31][CH:27]([NH:26][CH3:25])[CH2:28]4)=[N:17][C:18]=3[CH:19]=[CH:20][C:21]=2[Cl:22])=[O:11])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 117882683-(Methylamino)pyrrolidineHCID 1185559652,6-Dichloro-quinoline-5-carboxylic acid (4,4-difluorocyclohexylmethyl)-amide

Product 1

HCID 118566552HCID 118566552, compound

Procedure

The title compound was synthesized according to the procedure described in example 1 using 2,6-dichloro-quinoline-5-carboxylic acid (4,4-difluoro-cyclohexylmethyl)-amide, and methyl-pyrrolidin-3-yl-amine. 1H NMR (400 MHz, DMSO-d6): δ 8.73-8.76 (m, 1H), 7.70-7.73 (m, 1H), 7.48-7.54 (m, 2H), 6.94-6.96 (m, 1H), 3.53-3.56 (m, 3H), 3.22-3.29 (m, 4H), 2.31-2.34 (m, 5H), 2.01-2.13 (m, 3H), 1.73-1.86 (m, 6H), 1.23-1.32 (m, 2H). m/z: 458.2 [M+H]+

Sources & evidence

ORD record
ord-68911967d0bf451cb535e0b2bb9e5e9a
Source dataset
uspto-grants-2016_07
Patent number
US09399623B2

Reaction notes

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