Sodium Hydroxide → HCID 118556059, compound

Participants

Reaction Steps

1-{6-Chloro-5-[(4,4-difluoro-cyclohexylmethyl)-carbamoyl]-quinolin-2-yl}-piperidine-3-carboxylic acid ethyl ester was hydrolysed to the desired product with 2.5 M aqueous sodium hydroxide. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.41 (s, 1H), 8.72-8.75 (m, 1H), 7.73 (d, J=9.41 Hz, 1H), 7.50-7.56 (m, 2H), 7.35 (d, J=9.51 Hz, 1H), 4.48-4.51 (m, 1H), 4.18-4.21 (m, 1H), 3.15-3.25 (m, 4H), 2.48-2.52 (m, 1H), 1.97-2.03 (m, 3H), 1.82-1.85 (m, 3H), 1.63-1.76 (m, 4H), 1.45-1.51 (m, 1H), 1.27-1.31 (m, 2H). m/z: 466.3 [M+H]+

Provenance & Evidence