Triethylsilane → HCID 118566581, compound

Participants

Reaction Steps

The title compound was synthesized according to the procedure described in example 126 using 6-chloro-2-(3,6-dihydro-2H-pyran-4-yl)-quinoline-5-carboxylic acid (4,4-difluoro-cyclohexylmethyl)-amide, palladium on carbon and triethylsilane. 1H NMR (400 MHz, DMSO-d6): δ 8.80 (t, J=5.92 Hz, 1H), 7.97-8.04 (m, 2H), 7.77 (d, J=9.00 Hz, 1H), 7.62 (d, J=8.76 Hz, 1H), 3.96-4.00 (m, 2H), 3.45-3.52 (m, 2H), 3.25-3.27 (m, 2H), 3.11-3.17 (m, 1H), 2.01-2.04 (m, 2H), 1.80-1.90 (m, 7H), 1.74-1.77 (m, 2H), 1.23-1.33 (m, 2H). m/z: 423 [M+H]+

Provenance & Evidence