Azetidine hydrochloride → 2-(3-Azetidin-1-yl-cyclopentyl)-6-chloro-quinoline-5-carboxylic acid (4,4-difluoro cyclohexylmethyl)-amide

Participants

Reaction Steps

The title compound was synthesized according to the procedure described in example 133 using 6-chloro-2-(3-oxo-cyclopentyl)-quinoline-5-carboxylic acid (4,4-difluoro-cyclohexylmethyl)-amide, and azetidine hydrochloride. 1H NMR (400 MHz, DMSO-d6): δ 10.08 (m, 1H), 8.81 (t, J=4.41 Hz, 1H), 8.06-8.03 (m, 1H), 8.00-7.96 (m, 1H), 7.81-7.77 (m, 1H), 7.62-7.58 (m, 1H), 4.17-4.06 (m, 5H), 4.06-4.04 (m, 1H), 3.29-3.26 (m, 2H), 2.50-2.44 (m, 5H), 2.07-2.03 (m, 3H), 1.90-1.84 (m, 7H), 1.78-1.74 (m, 1H), 1.31-1.27 (m, 2H). m/z: 462.3 [M+H]+

Provenance & Evidence