Hydrochloride methanol → HCID 178418953, compound

HRID 10568Notes

Reaction equation

HRID 10568 reaction equation
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:26].CO>>[ClH:26].[CH:21]1[C:22]2[C:17](=[C:16]([O:15][C@H:12]3[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]3)[CH:25]=[CH:24][CH:23]=2)[CH:18]=[CH:19][N:20]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 178419085HCID 178419085, compound

Product 1

HCID 178418953HCID 178418953, compound

Procedure

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 123 (59.6 mg) and 10% hydrogen chloride/methanol solution (2 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (0.5 ml) and diethyl ether (1.5 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (52.8 mg).

Workup

  1. custom(room temperature, 2 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (0.5 ml) and diethyl ether (1.5 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Sources & evidence

ORD record
ord-e6ea173fbdad4a93b30eaab9957c3e20
Source dataset
uspto-grants-2006_08
Patent number
US07094789B2

Reaction notes

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