Cesium fluoride → HCID 118555944, compound

Participants

Reaction Steps

The title compound was synthesized according to the procedure described in example 125 using 2,6-dichloro-quinoline-5-carboxylic acid (4,4-difluoro-cyclohexylmethyl)-amide, cesium fluoride, 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester and bis(triphenylphosphine)palladium(II) dichloride. 1H NMR (400 MHz, DMSO-d6): δ 8.85 (t, J=5.82 Hz, 1H), 8.03-8.05 (m, 1H), 7.94-8.00 (m, 2H), 7.78 (d, J=9.01 Hz, 1H), 6.89 (s, 1H), 4.12 (s, 2H), 3.57 (t, J=5.5 Hz, 2H), 3.28 (t, J=6.23 Hz, 2H), 2.73 (s, 2H), 2.02-2.04 (m, 2H), 1.74-1.87 (m, 5H), 1.43 (s, 9H), 1.30-1.32 (m, 2H). m/z: 519.0 [M+H]+

Provenance & Evidence