2,4-Dihydroxybenzaldehyde → HCID 86713214, compound

Participants

Reaction Steps

Separately, 13.8 g (100 mmol) of 2,4-dihydroxybenzaldehyde was dissolved in 250 mL of acetonitrile and 32.5 g (100 mmol) of cesium carbonate was added at room temperature. To this solution, the solution of 2-chloromethylpyridine in acetonitrile prepared in advance was added dropwise at 50° C. over 4 hours and the mixture was stirred for 11 hours. After filtration, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=80/20 to 50/50) to give 6.10 g (27% yield) of the title compound as a white solid.

Provenance & Evidence