Lithium triethylborohydride → HCID 131734808, compound

Participants

Reaction Conditions

Reaction Steps

The SEM dilactam 10d (0.063 g, 0.0455 mmol, 1.0 eq.) was solubilised in THF (2.7) and cooled to −78° C. under a nitrogen atmosphere. Super hydride solution (1M in THF, 0.093 mL, 2.04 eq.) was added dropwise over 5 minutes. After 20 minutes an aliquot was washed with water for LCMS and TLC analysis. After 30 minutes water was added and the cold bath removed. The organic layer was extracted with EtOAc (2×10 mL) and the combined organic extracts washed with brine (10 mL), dried with MgSO4, filtered and the solvent removed under reduced pressure. The crude product was dissolved in MeOH/DCM/water (6:3:1) (0.01 M) and enough silica gel to form a thick stirring suspension.

Provenance & Evidence