6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one → HCID 118093879, compound

HRID 1056953Notes

Reaction equation

HRID 1056953 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([N+:17]([O-:19])=[O:18])=[C:11]([CH:13]=[CH:14][C:15]=1Br)[NH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20][N:21]1[CH:26]=[C:25](B2OC(C)(C)C(C)(C)O2)[C:24]2[CH:36]=[CH:37][N:38]([S:39]([C:42]3[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=3)(=[O:41])=[O:40])[C:23]=2[C:22]1=[O:49]>>[NH2:12][C:11]1[CH:13]=[CH:14][C:15]([C:25]2[C:24]3[CH:36]=[CH:37][N:38]([S:39]([C:42]4[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=4)(=[O:41])=[O:40])[C:23]=3[C:22](=[O:49])[N:21]([CH3:20])[CH:26]=2)=[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 867210626-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-oneHCID 118093876HCID 118093876, compound

Product 1

HCID 118093879HCID 118093879, compound

Procedure

This compound was synthesized according to the procedure of Example 10, Step 5, using 3-(benzyloxy)-4-bromo-2-nitroaniline and 6-methyl-1-[(4-methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one as the starting materials. LCMS calculated for C28H25N4O6S (M+H)+: m/z=545.1. found: 545.2.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-9f1553614a4c4798995a195813180825
Source dataset
uspto-grants-2016_07
Patent number
US09399640B2

Reaction notes

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