Acetyl chloride → HCID 118093877, compound

Participants

Reaction Steps

A solution of 5-bromo-4-(cyclobutylmethoxy)-1-methyl-3-(2-piperazin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one (40.0 mg, 0.0945 mmol) in methylene chloride (2.0 mL) was treated with N,N-diisopropylethylamine (49.4 μL, 0.283 mmol) followed by the addition of acetyl chloride (10.1 μL, 0.142 mmol), and the resultant reaction mixture was stirred at RT for 1 h. Purification by flash column chromatography (5% MeOH/EtOAc) gave the desired product (46 mg, 94%). LCMS calculated for C21H30BrN4O3 (M+H)+: m/z=465.1, 467.1. found: 465.1, 467.1.

Provenance & Evidence