6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one → HCID 118093774, compound

HRID 1056975Notes

Reaction equation

HRID 1056975 reaction equation
Br[C:2]1[C:3]([CH3:21])=[N:4][C:5]2[N:6]([N:17]=[C:18]([CH3:20])[CH:19]=2)[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1[F:16].[CH3:22][N:23]1[CH:28]=[C:27](B2OC(C)(C)C(C)(C)O2)[C:26]2[CH:38]=[CH:39][N:40]([S:41]([C:44]3[CH:49]=[CH:48][C:47]([CH3:50])=[CH:46][CH:45]=3)(=[O:43])=[O:42])[C:25]=2[C:24]1=[O:51]>>[F:16][C:10]1[CH:11]=[C:12]([F:15])[CH:13]=[CH:14][C:9]=1[O:8][C:7]1[N:6]2[N:17]=[C:18]([CH3:20])[CH:19]=[C:5]2[N:4]=[C:3]([CH3:21])[C:2]=1[C:27]1[C:26]2[CH:38]=[CH:39][N:40]([S:41]([C:44]3[CH:49]=[CH:48][C:47]([CH3:50])=[CH:46][CH:45]=3)(=[O:43])=[O:42])[C:25]=2[C:24](=[O:51])[N:23]([CH3:22])[CH:28]=1

Participants

3

Reactant 2

HCID 867210626-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-oneHCID 118093919HCID 118093919, compound

Product 1

HCID 118093774HCID 118093774, compound

Procedure

This compound was synthesized according to the procedure of Example 10, Step 5, using 6-bromo-7-(2,4-difluorophenoxy)-2,5-dimethylpyrazolo[1,5-a]pyrimidine and 6-methyl-1-[(4-methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one as the starting materials. LCMS calculated for C29H24F2N5O4S (M+H)+: m/z=576.1. found: 576.1.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-eb49fe4ec03e4c4593ce0841b51a7225
Source dataset
uspto-grants-2016_07
Patent number
US09399640B2

Reaction notes

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