HRID1056977

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)CNc1ccc(Br)c(Oc2ccc(F)cc2F)c1[N+](=O)[O-]

HCID118104364

未命名化合物

结构：Cn1cc(B2OC(C)(C)C(C)(C)O2)c2cnn(COCC[Si](C)(C)C)c2c1=O

HCID123366289

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CNc1ccc(-c2cn(C)c(=O)c3c2cnn3COCC[Si](C)(C)C)c(Oc2ccc(F)cc2F)c1[N+](=O)[O-]

HCID131736451

未命名化合物

PROCEDURE

实验过程

This compound was synthesized according to the procedure of Example 10, Step 5, using methyl {[4-bromo-3-(2,4-difluorophenoxy)-2-nitrophenyl]amino}acetate and 6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,6-dihydro-7H-pyrazolo[3,4-c]pyridin-7-one as the starting materials. LCMS calculated for C28H32F2N5O7Si (M+H)+: m/z=616.2. found: 616.2.

WORKUP

后处理

customThis compound was synthesized

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1e324410f94541eb9880e07be3d67a1e
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09399640B2
来源说明: uspto-grants-2016_07

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[C:4]([N+:14]([O-:16])=[O:15])[C:3]=1[O:17][C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=1[F:25].[CH3:26][N:27]1[CH:32]=[C:31](B2OC(C)(C)C(C)(C)O2)[C:30]2[CH:42]=[N:43][N:44]([CH2:45][O:46][CH2:47][CH2:48][Si:49]([CH3:52])([CH3:51])[CH3:50])[C:29]=2[C:28]1=[O:53]>>[F:25][C:19]1[CH:20]=[C:21]([F:24])[CH:22]=[CH:23][C:18]=1[O:17][C:3]1[C:4]([N+:14]([O-:16])=[O:15])=[C:5]([NH:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:6]=[CH:7][C:2]=1[C:31]1[C:30]2[CH:42]=[N:43][N:44]([CH2:45][O:46][CH2:47][CH2:48][Si:49]([CH3:50])([CH3:52])[CH3:51])[C:29]=2[C:28](=[O:53])[N:27]([CH3:26])[CH:32]=1