Phenol → 1-Bromo-4-methoxy-3-nitro-2-phenoxybenzene

HRID 1057004Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1F.[C:14]1([OH:20])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:20][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

Reactant 2

HCID 996Phenol

HCID 56776542Andecaliximab

Product 1

HCID 1180939601-Bromo-4-methoxy-3-nitro-2-phenoxybenzene

Procedure

This compound was synthesized according to the procedure of Example 1, Step 1, using 1-bromo-2-fluoro-4-methoxy-3-nitrobenzene and phenol as the starting materials.

Workup

customThis compound was synthesized

Sources & evidence

ORD record: ord-095e2369f9d641098e9b0583f4ce2bc1
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09399640B2

Reaction notes

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