Ethylorthoformate → HCID 118093824, compound

Participants

Reaction Steps

A solution of 2-amino-4-bromo-3-phenoxyphenol (0.075 g, 0.268 mmol) in ethyl orthoformate (0.405 mL, 2.43 mmol) was heated at 100° C. for 2.5 h. after which time the reaction mixture was cooled to RT and concentrated in vacuo to a crude residue. Purification by flash column chromatography (100% hexanes to 50% EtOAc/hexanes) gave the desired product (75.1 mg, 97%) as a white solid. LCMS calculated for C13H9BrNO2 (M+H)+: m/z=290.0, 292.0. found: 289.9, 291.9.

Provenance & Evidence