6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one → HCID 118093845, compound

HRID 1057011Notes

Reaction equation

HRID 1057011 reaction equation
Br[C:2]1[CH:12]=[CH:11][C:5]2[N:6]([CH3:10])[C:7](=[O:9])[NH:8][C:4]=2[C:3]=1[S:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH3:20][N:21]1[CH:26]=[C:25](B2OC(C)(C)C(C)(C)O2)[C:24]2[CH:36]=[CH:37][N:38]([S:39]([C:42]3[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=3)(=[O:41])=[O:40])[C:23]=2[C:22]1=[O:49]>>[CH3:10][N:6]1[C:5]2[CH:11]=[CH:12][C:2]([C:25]3[C:24]4[CH:36]=[CH:37][N:38]([S:39]([C:42]5[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=5)(=[O:41])=[O:40])[C:23]=4[C:22](=[O:49])[N:21]([CH3:20])[CH:26]=3)=[C:3]([S:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:4]=2[NH:8][C:7]1=[O:9]

Participants

3

Reactant 2

HCID 867210626-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-oneHCID 118093888HCID 118093888, compound

Product 1

HCID 118093845HCID 118093845, compound

Procedure

This compound was synthesized according to the procedure of Example 10, Step 5, using 5-bromo-1-methyl-4-(phenylthio)-1,3-dihydro-2H-benzimidazol-2-one and 6-methyl-1-[(4-methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one as the starting materials. LCMS calculated for C29H25N4O4S2 (M+H)+: m/z=557.1. found: 557.0.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-3c1c94efc61744c3ba667c388907b97d
Source dataset
uspto-grants-2016_07
Patent number
US09399640B2

Reaction notes

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