6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one → HCID 118093904, compound

HRID 1057013Notes

Reaction equation

HRID 1057013 reaction equation
Br[C:2]1[CH:12]=[CH:11][C:5]2[N:6]([CH3:10])[C:7](=[O:9])[NH:8][C:4]=2[C:3]=1[S:13][CH2:14][CH3:15].[CH3:16][N:17]1[CH:22]=[C:21](B2OC(C)(C)C(C)(C)O2)[C:20]2[CH:32]=[CH:33][N:34]([S:35]([C:38]3[CH:43]=[CH:42][C:41]([CH3:44])=[CH:40][CH:39]=3)(=[O:37])=[O:36])[C:19]=2[C:18]1=[O:45]>>[CH2:14]([S:13][C:3]1[C:4]2[NH:8][C:7](=[O:9])[N:6]([CH3:10])[C:5]=2[CH:11]=[CH:12][C:2]=1[C:21]1[C:20]2[CH:32]=[CH:33][N:34]([S:35]([C:38]3[CH:43]=[CH:42][C:41]([CH3:44])=[CH:40][CH:39]=3)(=[O:37])=[O:36])[C:19]=2[C:18](=[O:45])[N:17]([CH3:16])[CH:22]=1)[CH3:15]

Participants

3

Reactant 2

HCID 867210626-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-oneHCID 118093766HCID 118093766, compound

Product 1

HCID 118093904HCID 118093904, compound

Procedure

This compound was synthesized according to the procedure of Example 10, Step 5, using 5-bromo-4-(ethylthio)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one and 6-methyl-1-[(4-methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one as the starting materials. LCMS calculated for C25H25N4O4S2 (M+H)+: m/z=509.1. found: 509.1.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-709ffca0b9b14cc3aed767ef04fd41fc
Source dataset
uspto-grants-2016_07
Patent number
US09399640B2

Reaction notes

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