6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one → HCID 118093834, compound

HRID 1057015Notes

Reaction equation

HRID 1057015 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH2:9][C:8](=[O:11])[N:7]([CH3:12])[C:6]=2[C:13]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH3:21][N:22]1[CH:27]=[C:26](B2OC(C)(C)C(C)(C)O2)[C:25]2[CH:37]=[CH:38][N:39]([S:40]([C:43]3[CH:48]=[CH:47][C:46]([CH3:49])=[CH:45][CH:44]=3)(=[O:42])=[O:41])[C:24]=2[C:23]1=[O:50]>>[CH3:12][N:7]1[C:6]2[C:13]([O:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:2]([C:26]3[C:25]4[CH:37]=[CH:38][N:39]([S:40]([C:43]5[CH:48]=[CH:47][C:46]([CH3:49])=[CH:45][CH:44]=5)(=[O:42])=[O:41])[C:24]=4[C:23](=[O:50])[N:22]([CH3:21])[CH:27]=3)[CH:3]=[CH:4][C:5]=2[O:10][CH2:9][C:8]1=[O:11]

Participants

3

Reactant 2

HCID 867210626-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-oneHCID 118093842HCID 118093842, compound

Product 1

HCID 118093834HCID 118093834, compound

Procedure

This compound was synthesized according to the procedure of Example 10, Step 5, using 6-bromo-4-methyl-5-phenoxy-2H-1,4-benzoxazin-3(4H)-one and 6-methyl-1-[(4-methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one as the starting materials. LCMS calculated for C30H26N3O6S (M+H)+: m/z=556.2. found: 556.0.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-8c3beea4ba254916898d38789301183a
Source dataset
uspto-grants-2016_07
Patent number
US09399640B2

Reaction notes

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