Cyclobutanecarbonyl chloride → HCID 118093922, compound

HRID 1057021Notes

Reaction equation

[NH2:1][CH2:2][C:3]1[N:7]([CH3:8])[C:6]2[CH:9]=[CH:10][C:11]([C:20]3[C:21]4[CH:30]=[CH:29][N:28]([S:31]([C:34]5[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=5)(=[O:33])=[O:32])[C:22]=4[C:23](=[O:27])[N:24]([CH3:26])[CH:25]=3)=[C:12]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:5]=2[N:4]=1.[CH:41]1([C:45](Cl)=[O:46])[CH2:44][CH2:43][CH2:42]1>>[CH3:8][N:7]1[C:6]2[CH:9]=[CH:10][C:11]([C:20]3[C:21]4[CH:30]=[CH:29][N:28]([S:31]([C:34]5[CH:35]=[CH:36][C:37]([CH3:40])=[CH:38][CH:39]=5)(=[O:32])=[O:33])[C:22]=4[C:23](=[O:27])[N:24]([CH3:26])[CH:25]=3)=[C:12]([O:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:5]=2[N:4]=[C:3]1[CH2:2][NH:1][C:45]([CH:41]1[CH2:44][CH2:43][CH2:42]1)=[O:46]

Participants

Reactant 2

HCID 78705Cyclobutanecarbonyl chloride

HCID 118093846HCID 118093846, compound

Product 1

HCID 118093922HCID 118093922, compound

Procedure

This compound was synthesized according to the procedure of Example 66, Step 2, using 4-[2-(aminomethyl)-1-methyl-4-phenoxy-1H-benzimidazol-5-yl]-6-methyl-1-[(4-methylphenyl)sulfonyl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one and cyclobutanecarboxylic acid chloride as the starting materials. LCMS calculated for C35H34N5O5S (M+H)+: m/z=636.2. found: 636.2.

Workup

customThis compound was synthesized

Sources & evidence

ORD record: ord-ef59d110fb0746eb93a439b8049dcc4f
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09399640B2

Reaction notes

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