Tert-butyl 3-(2,6-dichloro-4-pyridyl)-2,5-dihydropyrrole-1-carboxylate → Tert-butyl 3-(2,6-dichloropyridin-4-yl)pyrrolidine-1-carboxylate

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Reaction Steps

A mixture of tert-butyl 3-(2,6-dichloro-4-pyridyl)-2,5-dihydropyrrole-1-carboxylate (126 mg, 0.399 mmol) and 5% Rh/C (20 mg) in absolute alcohol (12 mL) was purged with N2, then primed with H2 (balloon)/vacuum (3×), stirred under H2 balloon for o/n. It was purged with N2, filtered through Celite, washed the Celite with MeOH, concentrated in vacuo gave 121 mg (95.4%) of product as clear gum. It was carried on without further purification. LC-MS: m/z=318 (M+H+).

Provenance & Evidence