Hydrochloric Acid → HCID 90067629, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-[2-(3,3-difluoropyrrolidin-1-yl)-6-[[4-(trifluoromethyl)-2-pyridyl]amino]-4-pyridyl]azetidine-1-carboxylate (1-c, 918 mg, 1.562 mmol) in dioxane (6.0 ml, 70.30 mmol) was added hydrogen chloride (4.0 mol/l) in dioxane (16.0 mL, 40 equiv., 62.49 mmol), and the reaction was kept at 25° C. for 4 h. The reaction was neutralized by NaHCO3 to pH 9, and the aqueous layer was extracted by EtOAc. After evaporation of the organic layer, the crude was used without further purification. LCMS: m/z 400 (M+H).

Provenance & Evidence