反应详情

温度

70 °C

A suspension of Intermediate 121 (100 mg), tris(dibenzylideneacetone)dipalladium(0) (22.1 mg), 2-(di-tert-butylphosphino)biphenyl (33.9 mg) and sodium tert-butoxide (35.3 mg) in 0.5 N ammonia/dioxane solution (2 ml) was stirred at 70° C. for 22 hours. The reaction mixture was filtered through a Celite layer, and the solvent was evaporated under reduced pressure. Then, the residue was purified by silica gel column chromatography (chloroform:methanol=9:1) to obtain the title compound (36.1 mg).

1. filtrationThe reaction mixture was filtered through a Celite layer
2. customthe solvent was evaporated under reduced pressure
3. customThen, the residue was purified by silica gel column chromatography (chloroform:methanol=9:1)