Diisopropylamine → (Cyclobutylethynyl)trimethylsilane

Temperature

0 °C

To a solution of diisopropylamine (153 g, 1.52 mol) in anhydrous THF (1.0 L) at 0° C., n-butyllithium (2.5 M in hexane, 608 mL, 1.52 mol) was added dropwise. The mixture was stirred for 20 minutes at 0° C. and then cooled to −78° C. To this mixture, a solution of (6-chlorohex-1-yn-1-yl)trimethylsilane (144 g, 0.76 mol) in anhydrous THF (200 mL) was added dropwise. The resulting mixture was allowed to warm to room temperature and stirred for 16 h. The reaction mixture was carefully quenched at room temperature with saturated aqueous NH4Cl (500 mL), and then extracted with pentane (2×200 mL). The combined organic layers were washed with brine (500 mL) and dried over anhydrous Na2SO4. The solvent was evaporated on a rotary evaporator. The residue was distilled at 160-162° C./760 Torr to afford the title compound as a colorless liquid (81 g, yield 70%). 1H NMR (CDCl3, 400 MHz): δ 3.05-3.01 (m, 1H), 2.26-2.20 (m, 2H), 2.17-2.10 (m, 2H), 1.93-1.84 (m, 2H), 0.11 (s, 9H).

1. temperaturecooled to −78° C
2. temperatureto warm to room temperature
3. stirringstirred for 16 h
4. customThe reaction mixture was carefully quenched at room temperature with saturated aqueous NH4Cl (500 mL)
5. extractionextracted with pentane (2×200 mL)
6. washThe combined organic layers were washed with brine (500 mL)
7. dry with materialdried over anhydrous Na2SO4
8. customThe solvent was evaporated on a rotary evaporator
9. distillationThe residue was distilled at 160-162° C./760 Torr

ORD record

ord-347eee3c426f472a9bbbae85644adc50

Source dataset

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09399646B2