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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1057200Generated: November 4, 2026

Iodobenzene → (E)-3-(4-((E)-2-Phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylonitrile

https://huagongshe.com/reaction/1057200

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodobenzeneHCID 11575—
Reactant4-(2-Cyanovinyl)phenylboronic acidHCID 46738753—
Reactant5-(But-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazoleHCID 66793270—
Product(E)-3-(4-((E)-2-Phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylonitrileHCID 66802201—

Reaction Steps

The title compound was prepared from Intermediate 3, iodobenzene, and (E)-(4-(2-cyanovinyl)phenyl)boronic acid following General Procedure C. LCMS: 376 [(M-THP+H)+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09399646B2
Source datasetuspto-grants-2016_07
ORD IDord-49250e20851040679c345f3236b28ccd
Source noteuspto-grants-2016_07