Potassium Permanganate → HCID 66802165, compound

Participants

Reaction Steps

Potassium permanganate (5 mL of 1.0 M aqueous solution) was added to a solution of (E)-6-(2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)-2-naphthaldehyde (240 mg, 0.49 mmol) and acetone:H2O (2:1, 15 mL) at room temperature. The reaction was stirred for 3 h, quenched with sat. Na2SO3, acidified to pH 5 with 1.0 M aqueous HCl soln, and then extracted with 2× EtOAc. The organic layers were combined, washed with water then brine, dried over Na2SO4, and concentrated. The crude material was used without further purification. LCMS: 419 [(M-THP+H)+H]+.

Provenance & Evidence