Sodium Chloride → HCID 57376361, compound

HRID 1057216Notes

Reaction equation

HRID 1057216 reaction equation
[C:1]1(=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH:3]=[CH:2]1.[CH3:13][S-:14].[Na+].[Cl-].[Na+]>CO>[CH3:1][C:2]1[C:13](=[S:14])[C:6]2[C:5]([C:4](=[O:11])[CH:3]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2

Participants

5

Reactant 3

HCID 5234Sodium ChlorideHCID 85301,4-NaphthoquinoneHCID 4378561Sodium methanethiolate

Product 1

HCID 57376361HCID 57376361, compoundYield 14%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.617 mM 1,4-naphtoquinone was dissolved in 30 ml of methanol in 100 ml one-neck round flask, and 1.54 mM sodium thiomethoxide was added thereto and stirred overnight. 50 ml of saturated sodium chloride solution was added to the reaction mixture, followed by extraction three times with 50 ml of chloroform, and an organic layer was dehydrated with an anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the obtained residue was re-crystallized with methanol to produce 2-methylthio-1,4-naphthoquinone that was yellow crystal.

Workup

  1. extractionfollowed by extraction three times with 50 ml of chloroform
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customthe obtained residue was re-crystallized with methanol

Sources & evidence

ORD record
ord-8aa81f1c8eab4c0d9c744f2d870954ec
Source dataset
uspto-grants-2016_07
Patent number
US09400281B2

Reaction notes

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