Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-(Methylthiomethyl)-6-phenylthiothymine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Chloromethyl methyl sulfide | HCID 16916 | — |
| 반응물 | 5-Methyl-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one | HCID 18671027 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(Methylthiomethyl)-6-phenylthiothymine | HCID 53840395 | 8.1% |
반응 단계
To 4 ml of dimethylformamide, 0.17 ml (2.0 mmol) of chloromethylmethylsulfide, 0.47 g (2.0 mmol) of 6-phenylthiothymine, 0.56 ml (2.0 mmol) of triethylamine were added and allowed to react for 22 hours at room temperature. The reaction mixture was concentrated under reduced pressure and the residue was adsorbed on a silica gel column and eluted with chloroform. The eluate was concentrated and crystallized from ethyl acetate to obtain 45 mg of the target compound (Yield: 8%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE037979E1 |
| 출처 데이터셋 | uspto-grants-2003_02 |
| ORD ID | ord-331e78f44cf74847817221983cb31339 |
| 출처 메모 | uspto-grants-2003_02 |