3-Methoxybenzonitrile → HCID 12056226, compound

Participants

Reaction Conditions

Reaction Steps

3-Methoxybenzonitrile (1.31 g. 0.01 mole) and 2,2,3,3,3-pentafluoro-N-{2,2,2-trifluoro-1-(trifluoromethyl)ethylidene}propanamide (4.67 g., 0.015 mole) were dissolved in diethyl ether and heated in a glass ampoule to 60° C. for six hours. Solvent was evaporated off and the residue distilled at 119° to 120° C./13 min to give a colorless oil (361 g, 82 percent). PMR (CDCl3), 3.85 s (3H), 7.18 d (1H), 7.40 t (1H), 7.55 s (1H), 7.65 d (1H), 19F NMR, −45.74 (2F), −5.47 (3F), −1.12 (6F).

Provenance & Evidence