3-(Trifluoromethyl)benzonitrile → HCID 12056227, compound

Participants

Reaction Steps

3-Trifluoromethylbenzonitrile (1.69 g, 0.01 mole) and 2,2,3,3,3-pentafluoro-N-{2,2,2-trifluoro-1-(trifluoromethyl)ethylidene}propanamide (4.67 g, 0.015 mole) were dissolved in diethyl ether, sealed in an ampoule and kept at 60° C. for six hours. The solvent was evaporated and the residue distilled at reduced pressure to give a colorless oil, 4.4 g. (90 percent). PMR (CDCl3), 7.70 t (1H), 7.95 d (1H), 8.30 s&d (2H); 19F NMR, −45.68 (2F), −5.49 (3F), −10 (6F), 14.11 (3F).

Provenance & Evidence