反应详情

A solution of Intermediate 124 (90.5 mg) in methanol (5 ml) was added with platinum oxide (13 mg, Wako Pure Chemical Industries) and stirred for 15 hours under hydrogen atmosphere. The reaction mixture was filtered through a Celite layer, and the solvent was evaporated under reduced pressure. Then, the residue was purified by silica gel column chromatography (chloroform:methanol=20:1) to obtain the title compound (41.1 mg).

1. filtrationThe reaction mixture was filtered through a Celite layer
2. customthe solvent was evaporated under reduced pressure
3. customThen, the residue was purified by silica gel column chromatography (chloroform:methanol=20:1)