4-Chloro-2-fluoroaniline → N-(4-chloro-2-fluorophenyl)-6-methoxy-7-(2-methoxyethoxy)cinnolin-4-amine

Participants

Reaction Steps

A solution of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.4 g, 1.5 mmol), (prepared as described for the starting material in Example 2), and 4-chloro-2-fluoroaniline (282 μl, 2.5 mmol) in DMF (5 ml) was treated as described in Example 2, to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (450 mg, 72%).

Provenance & Evidence