Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1057324생성일: 2026년 10월 25일
4-Bromo-2-fluoroaniline → 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline
https://huagongshe.com/reaction/1057324
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Bromo-2-fluoroaniline | HCID 123050 | — |
| 반응물 | 4-Chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline | HCID 10707048 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline | HCID 21991041 | — |
반응 단계
A solution of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.2 g, 0.74 mmol), (prepared as described for the starting material in Example 2), and 4-bromo-2-fluoroaniline (155 mg, 0.82 mmol) in DMF (2.5 ml) was heated at 150° C. for 45 minutes. After cooling to ambient temperature the mixture was treated as described in Example 3 to give 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (150 mg, 44%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06514971B1 |
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| 출처 데이터셋 | uspto-grants-2003_02 |
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| ORD ID | ord-55f7f760f42a45839c33d335c6cc2222 |
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| 출처 메모 | uspto-grants-2003_02 |
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