Dimethylformamide → HCID 9969734, compound

Participants

Reaction Conditions

Reaction Steps

240 mg (2.21 mmol) of 1-piperidin-4-yl-1,3-dihydrobenzimidazol-2-one is dissolved in 3.5 ml of acetonitrile and 3.5 ml of DMF at 50° C. and at this temperature a solution of 240 mg (1.00 mmol) of the compound of Example 11.3 in 7.5 ml of ethyl acetate is added dropwise. The mixture is initially stirred for 5 hours at 50° C., then for 72 hours at RT. The solution is evaporated down and the residue is purified by flash chromatography (dichloromethane/ethanol 90:10), yielding 48 mg of product. MS: m/z 376 [(M+H)+]; melting point: 185° C.

Provenance & Evidence