HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxindole → N-methyl-2-oxoindoline-5-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxindole | HCID 321710 | — |
| Reactant | 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride | HCID 4962506 | — |
| Solvent | Methylamine | HCID 6329 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-methyl-2-oxoindoline-5-sulfonamide | HCID 10176909 | 88% |
Reaction Steps
A suspension of 3.38 g of 5-chlorosulfonyl-2-oxindole from the oxindole O-17 in 10 mL of 2 M methylamine in tetrahydrofuran was stirred at room temperature for 4 hours at which time a white solid was present. The precipitate was collected by vacuum filtration, washed twice with 5 mL of water each time and dried under vacuum at 40° C. overnight to give 3.0 g (88% yield) of 5-methylaminosulfonyl-2-oxindole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06514981B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-69f20c9c243c4dfa8a2e68887509dc3a |
| Source note | uspto-grants-2003_02 |