HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → N-benzyl-2-(2-bromophenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 2-Bromophenylacetic acid | HCID 87754 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-benzyl-2-(2-bromophenyl)acetamide | HCID 10892034 | — |
Reaction Steps
To a stirring solution of 2-bromophenylacetic acid in dichloromethane (0.2 M) was added benzylamine (1.2 eq), triethylamine (1.5 eq), and EDAC (1.5 eq). After 2 hrs, the solution was washed with water, 10% HCl, 10% sodium carbonate, and water, dried over magnesium sulfate, filtered and concentrated in vacuo to afford a colorless solid. EI-MS m/z 304/306 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06514964B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-6d0b0ea35d164f8db3e616738dba1dbe |
| Source note | uspto-grants-2003_02 |