Hydrochloric Acid → HCID 9909507, compound

Participants

Reaction Steps

Methyl 2-(3-({N-(4-(2-pyridylamino)but-1-yl)carbamoyl}methyl)-1H,2H,4H,5H-benzo[d]azepin-1-yl)acetate was dissolved in MeOH (0.1M) followed by addition of 1N NaOH (5 eq). After stirring overnight, 1N HCl (5 eq) was added, and the solution was concentrated in vacuo. Flash chromatography (10% MeOH/CHCl3) afforded a colorless solid. EI-MS m/z 411 (M+H)+; 1H NMR (400 MHz; D2O): 7.50 (2H, m), 6.93 (4H, m), 6.62 (1H, d, J=8.9 Hz), 6.51 (1H, t, J=6.7 Hz), 3.23 (1H, m), 3.01 (6H, m), 2.75 (2H, br), 2.57 (4H, m), 2.38 (2H, m), 1.36 (4H, br).

Provenance & Evidence