Putrescine → HCID 53913675, compound

HRID 1057486Notes

Reaction equation

HRID 1057486 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13]>N1C=CC=CC=1>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 1045PutrescineHCID 73277Chloropyrazine

Product 1

HCID 53913675HCID 53913675, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

(4-aminobutyl)pyrazin-2-ylamine was prepared by refluxing 2-chloropyrazine and 1,4-diaminobutane in pyridine (50 mL) for 18 hrs. The solution was then concentrated in vacuo and the residue was partitioned between ethyl acetate and 10% sodium carbonate. The phases were separated, and the organic phase was washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo. The desired product was isolated by flash chromatography using 10:1:1 Ethanol/Ammonium Hydroxide/water. EI-MS m/z 167 (M+H)+.

Workup

  1. custom(4-aminobutyl)pyrazin-2-ylamine was prepared
  2. concentrationThe solution was then concentrated in vacuo
  3. customthe residue was partitioned between ethyl acetate and 10% sodium carbonate
  4. customThe phases were separated
  5. washthe organic phase was washed with brine
  6. dry with materialdried over magnesium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5cfade5ce625454c8108a6b3861d450d
Source dataset
uspto-grants-2003_02
Patent number
US06514964B1

Reaction notes

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