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0 °C

Ethyl 4-acetylbutyrate was dissolved in MeOH (0.5M) and cooled to 0° C. Bromine (1.0 eq) was added dropwise and the mixture was stirred at room temperature for 18 hrs. The solvent was removed in vacuo and the residue was dissolved in ether, washed with water, saturated sodium bicarbonate, brine, dried over sodium sulfate. The solvent was removed in vacuo and the residue was purified by flash chromatograpy (7% EtOAc/Hexanes). EI-MS m/z 224 (M+H)+.

1. customThe solvent was removed in vacuo
2. dissolutionthe residue was dissolved in ether
3. washwashed with water, saturated sodium bicarbonate, brine
4. dry with materialdried over sodium sulfate
5. customThe solvent was removed in vacuo
6. customthe residue was purified by flash chromatograpy (7% EtOAc/Hexanes)